Chuk | conserved helix-loop-helix ubiquitous kinase

GeneMGI:99484Synonyms: IKKalpha, IkappaB kinase alpha, +7 more

Physiological systems

24 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Reproductive system Immune system Endocrine/exocrine gland Embryo Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Skeleton Craniofacial Mortality/aging

13 No significant impact

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:16Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal tooth morphology	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal testis morphology	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal limb morphology	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	homozygote	E18.5	N/A ^*
abnormal spleen morphology	2 supporting datasets	Chuk^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal embryo development	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	homozygote	E18.5	N/A ^*
enlarged lymph nodes	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Chuk^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Chuk.

Associated images

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Histopathology

There is no histopathology data found for Chuk.

IMPC related publications

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External links

No external links available for Chuk.

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*Chuk^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Chuk^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Chuk^{tm119289(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Chuk^{tm119289(L1L2_Pgk_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Chuk^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Chuk^{tm2e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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