Irs1 | insulin receptor substrate 1

GeneMGI:99454Synonyms: G972R, IRS-1

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Hematopoietic system Behavior/neurological Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Irs1^em1(IMPC)H	homozygote	Early adult	N/A ^*
increased mean platelet volume	1 supporting dataset	Irs1^em1(IMPC)H	heterozygote	Early adult	9.57x10^-6
increased freezing behavior	1 supporting dataset	Irs1^em1(IMPC)H	heterozygote	Early adult	4.25x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Irs1.

Associated images

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Histopathology

There is no histopathology data found for Irs1.

IMPC related publications

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External links

No external links available for Irs1.

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*Irs1^em1(IMPC)H*	Deletion	‌	mouse

My Genes