Xbp1 | X-box binding protein 1

GeneMGI:98970Synonyms: TREB-5, XBP-1, +2 more

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton Mortality/aging Renal/urinary system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:22Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



decreased red blood cell distribution width	1 supporting dataset	Xbp1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.91x10^-6
abnormal behavior	1 supporting dataset	Xbp1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.26x10^-7
abnormal bone mineralization	1 supporting dataset	Xbp1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.47x10^-5
abnormal lens morphology	1 supporting dataset	Xbp1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.27x10^-5
decreased T cell number	1 supporting dataset	Xbp1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.55x10^-5
increased body weight	1 supporting dataset	Xbp1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	5.98x10^-5
increased grip strength	2 supporting datasets	Xbp1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.68x10^-5
decreased circulating triglyceride level	1 supporting dataset	Xbp1^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.85x10^-5
preweaning lethality, complete penetrance	2 supporting datasets	Xbp1^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased mean corpuscular volume	1 supporting dataset	Xbp1^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.5x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Xbp1.

Associated images

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Histopathology

There is no histopathology data found for Xbp1.

IMPC related publications

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External links

No external links available for Xbp1.

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*Xbp1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Xbp1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Xbp1^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Xbp1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Xbp1^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Xbp1^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Xbp1^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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