Ucp1 | uncoupling protein 1 (mitochondrial, proton carrier)

GeneMGI:98894Synonyms: Slc25a7

Physiological systems

22 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Hematopoietic system Cardiovascular system

18 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



eye hemorrhage	1 supporting dataset	Ucp1^m1H	homozygote	Early adult	1.37x10^-8
increased hematocrit	1 supporting dataset	Ucp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	9.3x10^-5
thick ventricular wall	1 supporting dataset	Ucp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.86x10^-5
cornea vascularization	1 supporting dataset	Ucp1^m1H	homozygote	Early adult	2.54x10^-7
abnormal sinus arrhythmia	1 supporting dataset	Ucp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.07x10^-5
cataract	1 supporting dataset	Ucp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.31x10^-5
increased erythrocyte cell number	1 supporting dataset	Ucp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.38x10^-5
decreased circulating triglyceride level	1 supporting dataset	Ucp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.13x10^-5
increased hemoglobin content	1 supporting dataset	Ucp1^m1H	homozygote	Early adult	9.91x10^-6
abnormal lens morphology	1 supporting dataset	Ucp1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.67x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ucp1.

Associated images

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Histopathology

There is no histopathology data found for Ucp1.

IMPC related publications

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External links

No external links available for Ucp1.

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*Ucp1^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Ucp1^{tm1.1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	es cell mouse
*Ucp1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Ucp1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse

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