Tbx1 | T-box 1

GeneMGI:98493Synonyms: nmf219

Physiological systems

22 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Endocrine/exocrine gland Embryo Growth/size/body region Vision/eye Cardiovascular system Mortality/aging

14 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal blood vessel morphology	1 supporting dataset	Tbx1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Tbx1^em1(IMPC)Mbp	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Tbx1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Tbx1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*
embryonic growth retardation	1 supporting dataset	Tbx1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal blood vessel morphology	1 supporting dataset	Tbx1^em1(IMPC)Mbp	heterozygote	E15.5	N/A ^*
edema	1 supporting dataset	Tbx1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
persistence of hyaloid vascular system	1 supporting dataset	Tbx1^em1(IMPC)Mbp	heterozygote	Early adult	3.26x10^-8
abnormal placenta morphology	1 supporting dataset	Tbx1^em1(IMPC)Mbp	homozygote	E15.5	N/A ^*
abnormal pancreas morphology	1 supporting dataset	Tbx1^em1(IMPC)Mbp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tbx1.

Associated images

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Histopathology

There is no histopathology data found for Tbx1.

IMPC related publications

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External links

No external links available for Tbx1.

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*Tbx1^em1(IMPC)Mbp*	Exon Deletion	‌	mouse
*Tbx1^{tm364528(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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