Pomc | pro-opiomelanocortin-alpha

GeneMGI:97742Synonyms: gamma-melanocyte stimulating hormone, ACTH, +11 more

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Growth/size/body region Hematopoietic system Mortality/aging

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal spleen morphology	1 supporting dataset	Pomc^{em1(IMPC)Rbrc}	heterozygote	Late adult	N/A ^*
enlarged spleen	1 supporting dataset	Pomc^{em1(IMPC)Rbrc}	heterozygote	Late adult	N/A ^*
preweaning lethality, incomplete penetrance	1 supporting dataset	Pomc^{em1(IMPC)Rbrc}	homozygote	Early adult	N/A ^*
impaired glucose tolerance	1 supporting dataset	Pomc^{em1(IMPC)Rbrc}	heterozygote	Early adult	3.7x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

Download data as:

‌



‌	‌	‌	‌	‌	‌	‌	‌	‌	‌

* This parameter was manually assessed for significance.

Download data as:

lacZ Expression

No adult expression data available for Pomc.

Associated images

Loading...

Histopathology

There is no histopathology data found for Pomc.

IMPC related publications

Loading...

External links

No external links available for Pomc.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.



*Pomc^{em1(IMPC)Rbrc}*	Indel	‌	mouse
*Pomc^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Pomc^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Pomc^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes