Pgd | phosphogluconate dehydrogenase

GeneMGI:97553Synonyms: 0610042A05Rik

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Skeleton Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal bone structure	1 supporting dataset	Pgd^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.77x10^-8
increased circulating aspartate transaminase level	1 supporting dataset	Pgd^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.7x10^-13
preweaning lethality, complete penetrance	1 supporting dataset	Pgd^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral content	1 supporting dataset	Pgd^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.2x10^-7
abnormal bone mineralization	1 supporting dataset	Pgd^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.04x10^-11
increased lactate dehydrogenase level	1 supporting dataset	Pgd^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.84x10^-9
absent testes	1 supporting dataset	Pgd^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.88x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Pgd.

Associated images

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Histopathology

There is no histopathology data found for Pgd.

IMPC related publications

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External links

No external links available for Pgd.

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*Pgd^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Pgd^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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