Nras | neuroblastoma ras oncogene

GeneMGI:97376Synonyms: N-ras

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Limbs/digits/tail Skeleton Mortality/aging

15 No significant impact

5 Not tested

Gene metrics:4Significant phenotypes
15Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetNrastm1b(EUCOMM)HmguhomozygoteEarly adultN/A * 
increased circulating glucose level1 supporting datasetNrastm1b(EUCOMM)HmguheterozygoteEarly adult6.46x10-6 
increased circulating HDL cholesterol level1 supporting datasetNrastm1b(EUCOMM)HmguheterozygoteEarly adult8.48x10-5 
short tibia1 supporting datasetNrastm1b(EUCOMM)HmguheterozygoteEarly adult1.79x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Nrastm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
ES Cell
Nrastm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Nrastm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Nrastm1e(EUCOMM)HmguTargeted, non-conditional alleleES Cell
Nrastm373486(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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