Npr2 | natriuretic peptide receptor 2

GeneMGI:97372Synonyms: cn, guanylyl cyclase-B, +1 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Behavior/neurological Mortality/aging Craniofacial

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased grip strength	1 supporting dataset	Npr2^em1(IMPC)H	heterozygote	Early adult	7.41x10^-6
tremors	1 supporting dataset	Npr2^em1(IMPC)H	homozygote	Early adult	9.76x10^-9
trunk curl	1 supporting dataset	Npr2^em1(IMPC)H	homozygote	Early adult	1.18x10^-9
abnormal tail morphology	1 supporting dataset	Npr2^em1(IMPC)H	heterozygote	Early adult	1.51x10^-8
preweaning lethality, incomplete penetrance	1 supporting dataset	Npr2^em1(IMPC)H	homozygote	Early adult	N/A ^*
impaired cued conditioning behavior	1 supporting dataset	Npr2^em1(IMPC)H	homozygote	Early adult	3.26x10^-5
increased freezing behavior	2 supporting datasets	Npr2^em1(IMPC)H	homozygote	Early adult	1.73x10^-9
abnormal locomotor behavior	1 supporting dataset	Npr2^em1(IMPC)H	homozygote	Early adult	1.03x10^-10
abnormal head size	1 supporting dataset	Npr2^em1(IMPC)H	homozygote	Early adult	3.87x10^-8
abnormal hindlimb morphology	1 supporting dataset	Npr2^em1(IMPC)H	homozygote	Early adult	3.97x10^-13

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Npr2.

Associated images

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Histopathology

There is no histopathology data found for Npr2.

IMPC related publications

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External links

No external links available for Npr2.

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*Npr2^em1(IMPC)H*	Exon Deletion	‌	mouse
*Npr2^{tm380425(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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