Nfya | nuclear transcription factor-Y alpha

GeneMGI:97316Synonyms: Sez10, Cbf-b

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Pigmentation Adipose tissue Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Skeleton

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Allele:

Phy. System:



abnormal head morphology	2 supporting datasets	Nfya^{Gt(EUCJ0004f10)Hmgu}	heterozygote	Early adult	5.2x10^-17
decreased total body fat amount	1 supporting dataset	Nfya^{Gt(EUCJ0004f10)Hmgu}	heterozygote	Early adult	8.5x10^-5
decreased grip strength	1 supporting dataset	Nfya^{Gt(EUCJ0004f10)Hmgu}	heterozygote	Early adult	2.07x10^-5
increased circulating fructosamine level	1 supporting dataset	Nfya^{Gt(EUCJ0004f10)Hmgu}	heterozygote	Early adult	1.68x10^-5
increased circulating calcium level	1 supporting dataset	Nfya^Nfya	heterozygote	Early adult	7.26x10^-8
increased leukocyte cell number	1 supporting dataset	Nfya^{Gt(EUCJ0004f10)Hmgu}	heterozygote	Early adult	2.8x10^-5
abnormal eye morphology	1 supporting dataset	Nfya^{Gt(EUCJ0004f10)Hmgu}	heterozygote	Early adult	1.23x10^-5
increased bone mineral density	1 supporting dataset	Nfya^{Gt(EUCJ0004f10)Hmgu}	heterozygote	Early adult	6.91x10^-7
decreased body weight	1 supporting dataset	Nfya^{Gt(EUCJ0004f10)Hmgu}	heterozygote	Early adult	1.94x10^-7
thrombocytosis	1 supporting dataset	Nfya^Nfya	heterozygote	Early adult	1.12x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nfya.

Associated images

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Histopathology

There is no histopathology data found for Nfya.

IMPC related publications

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External links

No external links available for Nfya.

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*Nfya^{Gt(EUCJ0004f10)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Nfya^{tm169999(pL1L2_GT0_DelLacZ_bsd)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector
*Nfya^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Nfya^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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