Nek1 | NIMA (never in mitosis gene a)-related expressed kinase 1

GeneMGI:97303Synonyms: kat, D8Ertd790e, +1 more

Physiological systems

18 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Reproductive system Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Cardiovascular system Craniofacial

9 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal retina outer nuclear layer morphology	2 supporting datasets	Nek1^em1(IMPC)Bay	homozygote	Early adult	1.82x10^-90
decreased prepulse inhibition	5 supporting datasets	Nek1^em1(IMPC)Bay	homozygote	Early adult	2.48x10^-8
decreased bone mineral content	2 supporting datasets	Nek1^em1(IMPC)Bay	homozygote	Early adult	1.14x10^-16
abnormal pelvic girdle bone morphology	1 supporting dataset	Nek1^em1(IMPC)Bay	homozygote	Early adult	2.95x10^-5
decreased grip strength	3 supporting datasets	Nek1^em1(IMPC)Bay	homozygote	Early adult	3.14x10^-5
decreased cardiac stroke volume	1 supporting dataset	Nek1^em1(IMPC)Bay	homozygote	Early adult	1.53x10^-6
abnormal bone structure	1 supporting dataset	Nek1^em1(IMPC)Bay	homozygote	Early adult	3.11x10^-33
decreased body length	1 supporting dataset	Nek1^em1(IMPC)Bay	homozygote	Early adult	6.18x10^-31
decreased total retina thickness	2 supporting datasets	Nek1^em1(IMPC)Bay	homozygote	Early adult	2.13x10^-29
male infertility	1 supporting dataset	Nek1^em1(IMPC)Bay	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Nek1.

Associated images

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Histopathology

There is no histopathology data found for Nek1.

IMPC related publications

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External links

No external links available for Nek1.

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*Nek1^em1(IMPC)Bay*	Exon Deletion	‌	mouse
*Nek1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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