Alad | aminolevulinate, delta-, dehydratase

GeneMGI:96853Synonyms: Lv

Physiological systems

22 / 24 physiological systems tested

12 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Liver/biliary system Hematopoietic system Behavior/neurological Skeleton Mortality/aging Renal/urinary system

10 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal sternum morphology	1 supporting dataset	Alad^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Alad^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Alad^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Alad^em1(IMPC)Tcp	heterozygote	Early adult	1.05x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Alad^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Alad^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
embryonic lethality prior to organogenesis	1 supporting dataset	Alad^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
enlarged lymph nodes	1 supporting dataset	Alad^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
enlarged thymus	1 supporting dataset	Alad^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
decreased red blood cell distribution width	1 supporting dataset	Alad^em1(IMPC)Tcp	heterozygote	Late adult	5.59x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Alad.

Associated images

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Histopathology

There is no histopathology data found for Alad.

IMPC related publications

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External links

No external links available for Alad.

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*Alad^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Alad^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Alad^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Alad^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Alad^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell

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