Lrp1 | low density lipoprotein receptor-related protein 1

GeneMGI:96828Synonyms: b2b1554Clo, CD91, +1 more

Physiological systems

20 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Homeostasis/metabolism Embryo Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Craniofacial Mortality/aging Cardiovascular system

11 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

4Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



microphthalmia	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal embryo size	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal forebrain morphology	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
abnormal limb bud morphology	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
increased heart weight	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	heterozygote	Early adult	1.18x10^-5
hemorrhage	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	homozygote	E12.5	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	homozygote	Early adult	N/A ^*
increased circulating alkaline phosphatase level	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	heterozygote	Early adult	1.82x10^-5
abnormal lens morphology	1 supporting dataset	Lrp1^{tm1.1(KOMP)Wtsi}	heterozygote	Late adult	8.64x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lrp1.

Associated images

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Histopathology

There is no histopathology data found for Lrp1.

IMPC related publications

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External links

No external links available for Lrp1.

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*Lrp1^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector ES Cell mouse
*Lrp1^{tm1.1(KOMP)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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