Lmna | lamin A

GeneMGI:96794Synonyms: lamin A/C, Dhe

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Limbs/digits/tail Nervous system Vision/eye Skeleton Mortality/aging

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

31Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



abnormal cornea morphology	1 supporting dataset	Lmna^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.31x10^-5
cornea ulcer	1 supporting dataset	Lmna^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	3.59x10^-6
improved glucose tolerance	1 supporting dataset	Lmna^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.85x10^-6
abnormal optic disk morphology	1 supporting dataset	Lmna^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6.38x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Lmna^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
short tibia	1 supporting dataset	Lmna^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.33x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lmna.

Associated images

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Histopathology

There is no histopathology data found for Lmna.

IMPC related publications

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External links

No external links available for Lmna.

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*Lmna^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Lmna^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lmna^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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