Lcn2 | lipocalin 2

GeneMGI:96757Synonyms: NRL, 24p3, +2 more

Physiological systems

18 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

12 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:7Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

46Embryo tissues

Phenotypes

Phy. System:



increased heart weight	1 supporting dataset	Lcn2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	5.05x10^-9
decreased thigmotaxis	2 supporting datasets	Lcn2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.54x10^-5
increased mean corpuscular volume	1 supporting dataset	Lcn2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.21x10^-6
decreased circulating glucose level	1 supporting dataset	Lcn2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.34x10^-13
decreased circulating serum albumin level	1 supporting dataset	Lcn2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	2.64x10^-6
increased urine microalbumin level	1 supporting dataset	Lcn2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	1.3x10^-5
decreased circulating iron level	1 supporting dataset	Lcn2^{tm1b(KOMP)Wtsi}	homozygote	Early adult	4.98x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Lcn2.

Associated images

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Histopathology

There is no histopathology data found for Lcn2.

IMPC related publications

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External links

No external links available for Lcn2.

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*Lcn2^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Lcn2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Lcn2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Lcn2^{tm1b(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Lcn2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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