Hprt1 | hypoxanthine phosphoribosyltransferase 1

GeneMGI:96217Synonyms: Hprt, Hprt1

Physiological systems

20 / 24 physiological systems tested

3 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological

17 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased erythrocyte cell number	1 supporting dataset	Hprt1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.41x10^-6
increased mean corpuscular volume	1 supporting dataset	Hprt1^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	3.01x10^-6
decreased erythrocyte cell number	1 supporting dataset	Hprt1^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	3.83x10^-5
abnormal gait	1 supporting dataset	Hprt1^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	6.47x10^-9
increased circulating HDL cholesterol level	1 supporting dataset	Hprt1^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	4.49x10^-6
increased mean corpuscular volume	1 supporting dataset	Hprt1^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	3.4x10^-5
thrombocytopenia	1 supporting dataset	Hprt1^{tm1a(EUCOMM)Hmgu}	hemizygote	Early adult	3.01x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hprt1.

Associated images

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Histopathology

There is no histopathology data found for Hprt1.

IMPC related publications

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External links

No external links available for Hprt1.

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*Hprt1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse

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