Gjb3 | gap junction protein, beta 3

GeneMGI:95721Synonyms: connexin 31, Gjb-3, +3 more

Physiological systems

23 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Integument Embryo Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Liver/biliary system Hematopoietic system Mortality/aging Craniofacial

13 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

7Associated diseases

Expression examined in:73Adult tissues

85Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal auditory brainstem response	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	4.03x10^-5
embryonic growth retardation	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
increased mean corpuscular volume	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	5.67x10^-5
preweaning lethality, complete penetrance	3 supporting datasets	Gjb3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
pallor	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
edema	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal skin coloration	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
pale liver	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal embryo size	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*
abnormal craniofacial morphology	1 supporting dataset	Gjb3^{tm1.1(KOMP)Vlcg}	homozygote	E15.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gjb3.

Associated images

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Histopathology

There is no histopathology data found for Gjb3.

IMPC related publications

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External links

No external links available for Gjb3.

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*Gjb3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Gjb3^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Gjb3^{tm214962(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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