Folr1 | folate receptor alpha

GeneMGI:95568Synonyms: folate-binding protein 1, Folbp1, +3 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Endocrine/exocrine gland Embryo Growth/size/body region Cardiovascular system Mortality/aging Renal/urinary system

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

2Associated diseases

Expression examined in:73Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



embryonic lethality prior to tooth bud stage	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	homozygote	E12.5	N/A ^*
embryonic growth retardation	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	homozygote	E9.5	N/A ^*
increased circulating alanine transaminase level	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	6.91x10^-5
enlarged heart	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal kidney morphology	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Folr1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	N/A ^*
small testis	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	N/A ^*
abnormal cholesterol homeostasis	1 supporting dataset	Folr1^{tm1.1(KOMP)Vlcg}	heterozygote	Early adult	1.36x10^-10

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Folr1.

Associated images

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Histopathology

There is no histopathology data found for Folr1.

IMPC related publications

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External links

No external links available for Folr1.

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*Folr1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Folr1^{tm1(KOMP)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Folr1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse

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