Eng | endoglin
Physiological systems
22 / 24 physiological systems tested
11 Significantly impacted by the knock-out
Immune system Embryo Growth/size/body region Limbs/digits/tail Nervous system Hematopoietic system Skeleton Craniofacial Cardiovascular system Mortality/aging Renal/urinary system
11 No significant impact
2 Not tested
Data collections
Gene metrics:14Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal vitelline vasculature morphology | 1 supporting dataset | Engem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal visceral yolk sac morphology | 1 supporting dataset | Engem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal placenta morphology | 1 supporting dataset | Engem1(IMPC)Mbp | heterozygote | E15.5 | N/A * | ||
| preweaning lethality, complete penetrance | 3 supporting datasets | Engem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| prenatal lethality prior to heart atrial septation | 1 supporting dataset | Engem1(IMPC)Mbp | homozygote | E15.5 | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Engem1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| abnormal pharyngeal arch morphology | 1 supporting dataset | Engem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal heart morphology | 1 supporting dataset | Engem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| embryonic growth retardation | 1 supporting dataset | Engem1(IMPC)Mbp | homozygote | E9.5 | N/A * | ||
| abnormal neural tube morphology | 1 supporting dataset | Engem1(IMPC)Mbp | homozygote | E9.5 | N/A * |
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External links
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| Engem1(IMPC)Mbp | Exon Deletion | | mouse |
| Engtm196474(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |