Eif2s1 | eukaryotic translation initiation factor 2, subunit 1 alpha
Physiological systems
22 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Integument Nervous system Behavior/neurological Skeleton Mortality/aging
17 No significant impact
2 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| preweaning lethality, complete penetrance | 3 supporting datasets | Eif2s1em1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased startle reflex | 1 supporting dataset | Eif2s1em1(IMPC)Mbp | heterozygote | Early adult | 8.64x10-7 | ||
| increased bone mineral content | 2 supporting datasets | Eif2s1em1(IMPC)Mbp | heterozygote | Early adult | 1.81x10-8 | ||
| abnormal skin morphology | 2 supporting datasets | Eif2s1em1(IMPC)Mbp | heterozygote | Early adult | N/A * | ||
| decreased prepulse inhibition | 1 supporting dataset | Eif2s1em1(IMPC)Mbp | heterozygote | Early adult | 4.52x10-5 | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Eif2s1em1(IMPC)Mbp | homozygote | E9.5 | N/A * |
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External links
No external links available for Eif2s1.
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| Eif2s1em1(IMPC)Mbp | Exon Deletion | | mouse |
| Eif2s1tm1(NCOM)Mfgc | Reporter-tagged deletion allele (with selection cassette) | | targeting vector ES Cell |
| Eif2s1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Eif2s1tm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |