Dmd | dystrophin, muscular dystrophy

GeneMGI:94909Synonyms: Dp71, Dp427, +5 more

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

8Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased lean body mass	2 supporting datasets	Dmd^{em1(IMPC)Hmgu}	homozygote	Early adult	6.88x10^-15
increased circulating alkaline phosphatase level	1 supporting dataset	Dmd^{em1(IMPC)Hmgu}	homozygote	Early adult	3.95x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Dmd^{em1(IMPC)Hmgu}	homozygote	Early adult	0
decreased bone mineral content	2 supporting datasets	Dmd^{em1(IMPC)Hmgu}	homozygote	Early adult	3.13x10^-14
increased circulating aspartate transaminase level	1 supporting dataset	Dmd^{em1(IMPC)Hmgu}	hemizygote	Early adult	1.88x10^-56
decreased total body fat amount	2 supporting datasets	Dmd^{em1(IMPC)Hmgu}	hemizygote	Early adult	5.88x10^-6
increased circulating total protein level	1 supporting dataset	Dmd^{em1(IMPC)Hmgu}	homozygote	Early adult	8x10^-7
increased lean body mass	2 supporting datasets	Dmd^{em1(IMPC)Hmgu}	hemizygote	Early adult	3.25x10^-6
thrombocytosis	1 supporting dataset	Dmd^{em1(IMPC)Hmgu}	homozygote	Early adult	7.68x10^-10
increased circulating serum albumin level	1 supporting dataset	Dmd^{em1(IMPC)Hmgu}	homozygote	Early adult	2.35x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dmd.

Associated images

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Histopathology

There is no histopathology data found for Dmd.

IMPC related publications

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External links

No external links available for Dmd.

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*Dmd^{em1(IMPC)Hmgu}*	Exon Deletion	‌	mouse
*Dmd^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Dmd^{tm82520(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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