Csk | c-src tyrosine kinase

GeneMGI:88537

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

Embryo Growth/size/body region Nervous system Vision/eye Mortality/aging Cardiovascular system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:50Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal embryo turning	1 supporting dataset	Csk^{tm2b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal embryo development	1 supporting dataset	Csk^{tm2b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Csk^{tm2b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal retina inner nuclear layer morphology	2 supporting datasets	Csk^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	7.1x10^-9
abnormal retina vasculature morphology	1 supporting dataset	Csk^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	1.19x10^-6
abnormal embryo size	1 supporting dataset	Csk^{tm2b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
abnormal neural tube closure	1 supporting dataset	Csk^{tm2b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
decreased total retina thickness	2 supporting datasets	Csk^{tm2b(EUCOMM)Hmgu}	heterozygote	Early adult	2.72x10^-8
embryonic growth retardation	1 supporting dataset	Csk^{tm2b(EUCOMM)Hmgu}	homozygote	E9.5	N/A ^*
embryonic lethality prior to tooth bud stage	1 supporting dataset	Csk^{tm2b(EUCOMM)Hmgu}	homozygote	E12.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Csk.

Associated images

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Histopathology

There is no histopathology data found for Csk.

IMPC related publications

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External links

No external links available for Csk.

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*Csk^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Csk^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Csk^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Csk^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Csk^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Csk^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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