Col5a1 | collagen, type V, alpha 1

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Homeostasis/metabolism Behavior/neurological Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:4Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance1 supporting datasetCol5a1tm1a(EUCOMM)HmguhomozygoteEarly adultN/A * 
abnormal behavior1 supporting datasetCol5a1tm1a(EUCOMM)HmguheterozygoteEarly adult2.83x10-6 
increased circulating cholesterol level1 supporting datasetCol5a1tm1a(EUCOMM)HmguheterozygoteEarly adult3.74x10-5 
increased startle reflex1 supporting datasetCol5a1tm1a(EUCOMM)HmguheterozygoteEarly adult7.36x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Col5a1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Col5a1tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell
Col5a1tm26464(L1L2_gt1)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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