Atp1a1 | ATPase, Na+/K+ transporting, alpha 1 polypeptide

GeneMGI:88105Synonyms: Atpa-1

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Muscle Limbs/digits/tail Hematopoietic system Cardiovascular system Mortality/aging

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:17Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



abnormal skin morphology	2 supporting datasets	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal thymus morphology	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
thick ventricular wall	2 supporting datasets	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.41x10^-6
abnormal digit morphology	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	4.55x10^-7
decreased heart rate	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	2.05x10^-5
enlarged heart	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
abnormal uterus morphology	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
enlarged thymus	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	heterozygote	Early adult	N/A ^*
preweaning lethality, complete penetrance	1 supporting dataset	Atp1a1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atp1a1.

Associated images

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Histopathology

There is no histopathology data found for Atp1a1.

IMPC related publications

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External links

No external links available for Atp1a1.

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*Atp1a1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Atp1a1^{tm1(NCOM)Cmhd}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell

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