Dagla | diacylglycerol lipase, alpha

GeneMGI:2677061Synonyms: Nsddr

Physiological systems

21 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Immune system Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Nervous system Respiratory system Liver/biliary system Hematopoietic system Behavior/neurological Cardiovascular system

11 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

1Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased thigmotaxis	2 supporting datasets	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.8x10^-5
increased startle reflex	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	5.27x10^-6
small heart	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
decreased brain size	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
small lung	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal behavior	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	2.9x10^-5
small liver	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
small stomach	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
small thymus	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
small spleen	1 supporting dataset	Dagla^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dagla.

Associated images

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Histopathology

There is no histopathology data found for Dagla.

IMPC related publications

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External links

No external links available for Dagla.

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*Dagla^{tm1(EGFP/cre/ERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Dagla^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Dagla^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Dagla^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Dagla^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell
*Dagla^{tm40176(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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