Grhl3 | grainyhead like transcription factor 3

GeneMGI:2655333Synonyms: ct, Som, +1 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Vision/eye Behavior/neurological Mortality/aging

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:12Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased circulating triglyceride level	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	7.71x10^-6
increased circulating calcium level	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.6x10^-5
increased startle reflex	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.21x10^-6
decreased circulating alkaline phosphatase level	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.28x10^-10
increased circulating glucose level	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.76x10^-7
increased circulating phosphate level	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.67x10^-7
preweaning lethality, complete penetrance	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
abnormal eye morphology	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.22x10^-5
decreased blood urea nitrogen level	1 supporting dataset	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.92x10^-6
abnormal retina morphology	2 supporting datasets	Grhl3^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.66x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Grhl3.

Associated images

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Histopathology

There is no histopathology data found for Grhl3.

IMPC related publications

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External links

No external links available for Grhl3.

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*Grhl3^{tm1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Grhl3^{tm1.1(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	es cell
*Grhl3^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Grhl3^{tm2(EGFP_CreERT2)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Grhl3^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Grhl3^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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