Pttg1ip | pituitary tumor-transforming 1 interacting protein

GeneMGI:2652132Synonyms: 1810010L20Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton

13 No significant impact

7 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased total body fat amount3 supporting datasetsPttg1ipem1(IMPC)HhomozygoteEarly adult2.44x10-6 
increased bone mineral content2 supporting datasetsPttg1ipem1(IMPC)HhomozygoteEarly adult0 
increased circulating alkaline phosphatase level1 supporting datasetPttg1ipem1(IMPC)HhomozygoteEarly adult4.77x10-5 
decreased lean body mass4 supporting datasetsPttg1ipem1(IMPC)HhomozygoteEarly adult0 
increased bone mineral density1 supporting datasetPttg1ipem1(IMPC)HhomozygoteEarly adult3.1x10-13 
increased blood urea nitrogen level1 supporting datasetPttg1ipem1(IMPC)HhomozygoteEarly adult1.36x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Pttg1ipem1(IMPC)HExon Deletionmouse
Pttg1iptm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)es cell
Pttg1iptm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
Pttg1iptm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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