Gars1 | glycyl-tRNA synthetase 1

GeneMGI:2449057Synonyms: Gena201, Gars, +2 more

Physiological systems

22 / 24 physiological systems tested

14 Significantly impacted by the knock-out

Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Digestive/alimentary Hematopoietic system Cardiovascular system Renal/urinary system Homeostasis/metabolism Vision/eye Behavior/neurological Skeleton Mortality/aging

8 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:13Significant phenotypes

5Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased exploration in new environment	1 supporting dataset	Gars1^em1(IMPC)Tcp	heterozygote	Early adult	1.46x10^-5
abnormal seminal vesicle morphology	1 supporting dataset	Gars1^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
abnormal skin morphology	1 supporting dataset	Gars1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
enlarged urinary bladder	1 supporting dataset	Gars1^em1(IMPC)Tcp	heterozygote	Late adult	N/A ^*
small spleen	1 supporting dataset	Gars1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
increased circulating triglyceride level	1 supporting dataset	Gars1^em1(IMPC)Tcp	heterozygote	Early adult	8.66x10^-5
embryonic lethality prior to organogenesis	1 supporting dataset	Gars1^em1(IMPC)Tcp	homozygote	E9.5	N/A ^*
preweaning lethality, complete penetrance	3 supporting datasets	Gars1^em1(IMPC)Tcp	homozygote	Early adult	N/A ^*
abnormal sternum morphology	1 supporting dataset	Gars1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*
abnormal stomach morphology	1 supporting dataset	Gars1^em1(IMPC)Tcp	heterozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Gars1.

Associated images

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Histopathology

There is no histopathology data found for Gars1.

IMPC related publications

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External links

No external links available for Gars1.

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*Gars1^em1(IMPC)Tcp*	Exon Deletion	‌	mouse
*Gars1^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Gars1^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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