Eif2b5 | eukaryotic translation initiation factor 2B, subunit 5 epsilon

GeneMGI:2446176

Physiological systems

15 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Hematopoietic system Skeleton

11 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

6Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal bone structure	1 supporting dataset	Eif2b5^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	8.35x10^-6
increased circulating creatinine level	1 supporting dataset	Eif2b5^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	6.79x10^-6
decreased granulocyte number	1 supporting dataset	Eif2b5^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.24x10^-7
decreased mean corpuscular volume	1 supporting dataset	Eif2b5^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.96x10^-10
decreased circulating glucose level	1 supporting dataset	Eif2b5^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.95x10^-6
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Eif2b5^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.01x10^-7
increased bone mineral density	1 supporting dataset	Eif2b5^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.45x10^-7
abnormal bone mineralization	1 supporting dataset	Eif2b5^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.93x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Eif2b5.

Associated images

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Histopathology

There is no histopathology data found for Eif2b5.

IMPC related publications

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External links

No external links available for Eif2b5.

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*Eif2b5^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Eif2b5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Eif2b5^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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