Atad2b | ATPase family, AAA domain containing 2B

GeneMGI:2444798Synonyms: D530031C13Rik, 1110014E10Rik

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Limbs/digits/tail Hearing/vestibular/ear Hematopoietic system Behavior/neurological Skeleton Renal/urinary system

11 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased circulating cholesterol level	1 supporting dataset	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.05x10^-8
abnormal auditory brainstem response	1 supporting dataset	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	3.62x10^-5
decreased exploration in new environment	1 supporting dataset	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	8.49x10^-6
long tibia	2 supporting datasets	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.72x10^-11
abnormal contextual conditioning behavior	3 supporting datasets	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6x10^-6
decreased NK T cell number	1 supporting dataset	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.44x10^-5
decreased circulating HDL cholesterol level	1 supporting dataset	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.08x10^-5
hyperactivity	1 supporting dataset	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	6.2x10^-5
abnormal kidney morphology	1 supporting dataset	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal motor capabilities/coordination/movement	1 supporting dataset	Atad2b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.1x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Atad2b.

Associated images

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Histopathology

There is no histopathology data found for Atad2b.

IMPC related publications

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External links

No external links available for Atad2b.

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*Atad2b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Atad2b^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Atad2b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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