Dars2 | aspartyl-tRNA synthetase 2 (mitochondrial)

GeneMGI:2442510Synonyms: 5830468K18Rik

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

Homeostasis/metabolism Mortality/aging

15 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:2Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



increased circulating LDL cholesterol level	1 supporting dataset	Dars2^{tm1a(KOMP)Wtsi}	heterozygote	Early adult	1.12x10^-6
preweaning lethality, complete penetrance	1 supporting dataset	Dars2^{tm1a(KOMP)Wtsi}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Dars2.

Associated images

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Histopathology

There is no histopathology data found for Dars2.

IMPC related publications

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External links

No external links available for Dars2.

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*Dars2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Dars2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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