Cgas | cyclic GMP-AMP synthase

GeneMGI:2442261Synonyms: Mb21d1, E330016A19Rik

Physiological systems

17 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Behavior/neurological Skeleton

13 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



abnormal behavior	2 supporting datasets	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	8.88x10^-5
increased circulating aspartate transaminase level	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.71x10^-11
abnormal glucose homeostasis	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.57x10^-5
abnormal bone mineralization	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	5.67x10^-5
decreased grip strength	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	2.06x10^-5
abnormal tail movements	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.24x10^-7
increased lactate dehydrogenase level	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	5.53x10^-9
increased startle reflex	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	4.09x10^-8
decreased circulating amylase level	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	8.25x10^-5
decreased prepulse inhibition	1 supporting dataset	Cgas^{tm1a(EUCOMM)Hmgu}	homozygote	Early adult	1.77x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Cgas.

Associated images

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Histopathology

There is no histopathology data found for Cgas.

IMPC related publications

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External links

No external links available for Cgas.

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*Cgas^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Cgas^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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