Pld5 | phospholipase D family member 5
Physiological systems
20 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Hematopoietic system Skeleton
16 No significant impact
4 Not tested
Data collections
Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
| decreased lean body mass | 1 supporting dataset | Pld5tm1b(KOMP)Wtsi | homozygote | Early adult | 5.55x10-6 | ||
| increased circulating HDL cholesterol level | 1 supporting dataset | Pld5tm1b(KOMP)Wtsi | homozygote | Early adult | 3.71x10-5 | ||
| decreased mean platelet volume | 1 supporting dataset | Pld5tm1b(KOMP)Wtsi | homozygote | Early adult | 9.11x10-6 | ||
| increased lactate dehydrogenase level | 1 supporting dataset | Pld5tm1a(KOMP)Wtsi | homozygote | Early adult | 2.67x10-5 | ||
| abnormal vertebral arch morphology | 1 supporting dataset | Pld5tm1b(KOMP)Wtsi | homozygote | Early adult | 1.74x10-5 | ||
| decreased red blood cell distribution width | 1 supporting dataset | Pld5tm1b(KOMP)Wtsi | homozygote | Early adult | 4.51x10-5 |
| | | | | | | | | | |
| adrenal gland | heterozygote | n/a | 0% (0/2) | 0.7% (4/570) |
| aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
| blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
| bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
| brain | heterozygote | n/a | 0% (0/2) | 0.86% (5/579) |
| brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
| brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
| cartilage tissue | heterozygote | n/a | 0% (0/2) | 0.22% (1/454) |
| cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
| cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
Human diseases caused by Pld5 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Pld5.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
| Pld5tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pld5tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pld5tm42650(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |