Mrps35 | mitochondrial ribosomal protein S35

GeneMGI:2385255Synonyms: MDSO23, MRPS28, +1 more

Physiological systems

20 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Skeleton Mortality/aging

15 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



preweaning lethality, complete penetrance	1 supporting dataset	Mrps35^{tm1a(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
increased bone mineral content	1 supporting dataset	Mrps35^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	9.2x10^-6
abnormal bone structure	1 supporting dataset	Mrps35^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.65x10^-7
abnormal bone mineralization	1 supporting dataset	Mrps35^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.39x10^-7
increased circulating creatinine level	1 supporting dataset	Mrps35^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	4.51x10^-5
increased lean body mass	2 supporting datasets	Mrps35^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	3.39x10^-7
increased lactate dehydrogenase level	1 supporting dataset	Mrps35^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	1.29x10^-5
increased total body fat amount	1 supporting dataset	Mrps35^{tm1a(EUCOMM)Wtsi}	heterozygote	Early adult	2.26x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mrps35.

Associated images

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Histopathology

There is no histopathology data found for Mrps35.

IMPC related publications

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External links

No external links available for Mrps35.

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*Mrps35^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Mrps35^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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