Nae1 | NEDD8 activating enzyme E1 subunit 1
Physiological systems
19 / 24 physiological systems tested
4 Significantly impacted by the knock-out
Homeostasis/metabolism Hematopoietic system Behavior/neurological Mortality/aging
15 No significant impact
5 Not tested
Data collections
Gene metrics:8Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
21Embryo tissues
| increased fasting circulating glucose level | 1 supporting dataset | Nae1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.21x10-5 | ||
| embryonic lethality prior to tooth bud stage | 1 supporting dataset | Nae1tm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
| increased mean corpuscular volume | 1 supporting dataset | Nae1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 2.09x10-5 | ||
| decreased erythrocyte cell number | 1 supporting dataset | Nae1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.04x10-5 | ||
| decreased exploration in new environment | 1 supporting dataset | Nae1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.31x10-8 | ||
| increased circulating phosphate level | 1 supporting dataset | Nae1tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.26x10-6 | ||
| preweaning lethality, complete penetrance | 1 supporting dataset | Nae1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
| embryonic lethality prior to organogenesis | 1 supporting dataset | Nae1tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * |
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External links
No external links available for Nae1.
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| Nae1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
| Nae1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Nae1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | es cell |