Tpcn1 | two pore channel 1

GeneMGI:2182472Synonyms: 5730403B01Rik

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Homeostasis/metabolism Hematopoietic system Behavior/neurological Renal/urinary system

16 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:5Significant phenotypes

0Associated diseases

Expression examined in:48Adult tissues

42Embryo tissues

Phenotypes

Allele:

Phy. System:



decreased mean corpuscular hemoglobin	1 supporting dataset	Tpcn1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.52x10^-11
increased urine microalbumin level	1 supporting dataset	Tpcn1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	3.54x10^-5
decreased mean corpuscular volume	1 supporting dataset	Tpcn1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.44x10^-7
decreased urine magnesium level	1 supporting dataset	Tpcn1^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	5.53x10^-11
abnormal behavior	2 supporting datasets	Tpcn1^Gt(XG716)Byg	homozygote	Early adult	1.95x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tpcn1.

Associated images

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Histopathology

There is no histopathology data found for Tpcn1.

IMPC related publications

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External links

No external links available for Tpcn1.

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*Tpcn1^Gt(XG716)Byg*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Tpcn1^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell mouse
*Tpcn1^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
	KO first allele (reporter-tagged insertion with conditional potential)	‌	es cell

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