Edem1 | ER degradation enhancer, mannosidase alpha-like 1

GeneMGI:2180139Synonyms: A130059K23Rik

Physiological systems

16 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hematopoietic system Skeleton

11 No significant impact

8 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:6Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:

Life Stage:



decreased total body fat amount	1 supporting dataset	Edem1^{em1(IMPC)Kmpc}	homozygote	Late adult	4.1x10^-10
increased mean platelet volume	1 supporting dataset	Edem1^{em1(IMPC)Kmpc}	homozygote	Late adult	1.84x10^-9
increased circulating HDL cholesterol level	1 supporting dataset	Edem1^{em1(IMPC)Kmpc}	homozygote	Late adult	7.11x10^-6
increased bone mineral content	1 supporting dataset	Edem1^{em1(IMPC)Kmpc}	homozygote	Late adult	2.87x10^-12
increased circulating calcium level	1 supporting dataset	Edem1^{em1(IMPC)Kmpc}	homozygote	Late adult	3.81x10^-5
increased lean body mass	1 supporting dataset	Edem1^{em1(IMPC)Kmpc}	homozygote	Late adult	1.08x10^-9
increased mean platelet volume	1 supporting dataset	Edem1^{em1(IMPC)Kmpc}	homozygote	Early adult	6.29x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Edem1.

Associated images

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Histopathology

There is no histopathology data found for Edem1.

IMPC related publications

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External links

No external links available for Edem1.

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*Edem1^{em1(IMPC)Kmpc}*	Indel	‌	mouse
*Edem1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Edem1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

My Genes