Asb7 | ankyrin repeat and SOCS box-containing 7

GeneMGI:2152835Synonyms: Asb-7, D030055C23Rik

Physiological systems

21 / 24 physiological systems tested

11 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Integument Growth/size/body region Muscle Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system Renal/urinary system

10 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:20Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased locomotor activity	1 supporting dataset	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.26x10^-5
increased circulating alkaline phosphatase level	1 supporting dataset	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.74x10^-7
abnormal eye morphology	2 supporting datasets	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal spleen morphology	2 supporting datasets	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased cardiac muscle contractility	2 supporting datasets	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.38x10^-5
decreased grip strength	1 supporting dataset	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.68x10^-5
decreased exploration in new environment	1 supporting dataset	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.81x10^-10
enlarged heart	1 supporting dataset	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased CD8-positive, alpha-beta T cell number	1 supporting dataset	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.04x10^-5
increased fasting circulating glucose level	1 supporting dataset	Asb7^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.13x10^-15

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Asb7.

Associated images

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Histopathology

There is no histopathology data found for Asb7.

IMPC related publications

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External links

No external links available for Asb7.

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*Asb7^{em1(IMPC)Ccpcz}*	Intra-exon deletion	‌	mouse
*Asb7^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Asb7^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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