Spred1 | sprouty protein with EVH-1 domain 1, related sequence

GeneMGI:2150016Synonyms: 5730461F13Rik, Spred-1

Physiological systems

21 / 24 physiological systems tested

13 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Integument Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Craniofacial

8 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:51Significant phenotypes

2Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased CD4-positive NK T cell number	1 supporting dataset	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.46x10^-12
abnormal lymph node morphology	1 supporting dataset	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
enlarged thymus	2 supporting datasets	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
vertebral fusion	1 supporting dataset	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	5.27x10^-5
abnormal retina morphology	1 supporting dataset	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.59x10^-9
abnormal spleen morphology	2 supporting datasets	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
anophthalmia	1 supporting dataset	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
decreased circulating alkaline phosphatase level	1 supporting dataset	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.16x10^-28
enlarged spleen	2 supporting datasets	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
abnormal startle reflex	1 supporting dataset	Spred1^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.71x10^-8

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Spred1.

Associated images

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Histopathology

There is no histopathology data found for Spred1.

IMPC related publications

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External links

No external links available for Spred1.

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*Spred1^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Spred1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Spred1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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