Fbxo11 | F-box protein 11

GeneMGI:2147134Synonyms: Jf, GENA 104

Physiological systems

22 / 24 physiological systems tested

10 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Limbs/digits/tail Nervous system Vision/eye Digestive/alimentary Hematopoietic system Behavior/neurological Skeleton Mortality/aging

12 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:24Significant phenotypes

1Associated diseases

Expression examined in:46Adult tissues

42Embryo tissues

Phenotypes

Zygosity:

Allele:

Phy. System:



abnormal bone mineralization	1 supporting dataset	Fbxo11^Jf	heterozygote	Early adult	8.65x10^-5
decreased circulating iron level	1 supporting dataset	Fbxo11^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	1.23x10^-6
increased startle reflex	6 supporting datasets	Fbxo11^Jf	heterozygote	Early adult	1.01x10^-19
hyperactivity	8 supporting datasets	Fbxo11^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	6.54x10^-7
decreased prepulse inhibition	4 supporting datasets	Fbxo11^Jf	heterozygote	Early adult	2.73x10^-7
decreased hemoglobin content	1 supporting dataset	Fbxo11^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	2.28x10^-11
decreased mean corpuscular volume	1 supporting dataset	Fbxo11^Jf	heterozygote	Early adult	5.16x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Fbxo11^Jf	homozygote	Early adult	N/A ^*
decreased hematocrit	1 supporting dataset	Fbxo11^{tm2b(EUCOMM)Wtsi}	heterozygote	Early adult	3.18x10^-8
abnormal defecation	1 supporting dataset	Fbxo11^Jf	heterozygote	Early adult	6.95x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fbxo11.

Associated images

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Histopathology

There is no histopathology data found for Fbxo11.

IMPC related publications

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External links

No external links available for Fbxo11.

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*Fbxo11^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell
*Fbxo11^{tm1e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell
*Fbxo11^{tm2a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Fbxo11^{tm2b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fbxo11^{tm2e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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