Ttbk1 | tau tubulin kinase 1

GeneMGI:2147036Synonyms: C330008L01Rik

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Adipose tissue Growth/size/body region Hearing/vestibular/ear Behavior/neurological

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:14Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased exploration in new environment	1 supporting dataset	Ttbk1^em1(IMPC)J	homozygote	Early adult	1.13x10^-5
increased anxiety-related response	1 supporting dataset	Ttbk1^em1(IMPC)J	homozygote	Early adult	3.6x10^-6
decreased locomotor activity	2 supporting datasets	Ttbk1^em1(IMPC)J	homozygote	Early adult	3.92x10^-5
abnormal behavior	1 supporting dataset	Ttbk1^em1(IMPC)J	homozygote	Early adult	1.01x10^-5
increased circulating glucose level	1 supporting dataset	Ttbk1^em1(IMPC)J	homozygote	Early adult	2.33x10^-8
tremors	1 supporting dataset	Ttbk1^em1(IMPC)J	homozygote	Early adult	7.39x10^-7
decreased total body fat amount	2 supporting datasets	Ttbk1^em1(IMPC)J	homozygote	Early adult	4.33x10^-5
increased lean body mass	2 supporting datasets	Ttbk1^em1(IMPC)J	homozygote	Early adult	1x10^-5
increased thigmotaxis	2 supporting datasets	Ttbk1^em1(IMPC)J	homozygote	Early adult	1.01x10^-5
decreased circulating cholesterol level	1 supporting dataset	Ttbk1^em1(IMPC)J	homozygote	Early adult	3.86x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Ttbk1.

Associated images

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Histopathology

There is no histopathology data found for Ttbk1.

IMPC related publications

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External links

No external links available for Ttbk1.

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*Ttbk1^em1(IMPC)J*	Exon Deletion	‌	mouse
*Ttbk1^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Ttbk1^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	ES Cell

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