Strn4 | striatin, calmodulin binding protein 4

GeneMGI:2142346Synonyms: ZIN, zinedin

Physiological systems

22 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

17 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:11Significant phenotypes

0Associated diseases

Expression examined in:78Adult tissues

35Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



decreased mean corpuscular hemoglobin	1 supporting dataset	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	4.96x10^-5
decreased thigmotaxis	2 supporting datasets	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.6x10^-7
abnormal behavior	1 supporting dataset	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	7.6x10^-7
decreased mean corpuscular hemoglobin concentration	1 supporting dataset	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.09x10^-5
no spontaneous movement	1 supporting dataset	Strn4^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
increased bone mineral density	1 supporting dataset	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.67x10^-5
decreased total retina thickness	2 supporting datasets	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	3.62x10^-5
abnormal retina morphology	1 supporting dataset	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	2.71x10^-5
increased bone mineral content	1 supporting dataset	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6.25x10^-5
decreased anxiety-related response	1 supporting dataset	Strn4^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	1.11x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Strn4.

Associated images

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Histopathology

There is no histopathology data found for Strn4.

IMPC related publications

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External links

No external links available for Strn4.

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*Strn4^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Strn4^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Strn4^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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