Pcsk9 | proprotein convertase subtilisin/kexin type 9
Physiological systems
19 / 24 physiological systems tested
1 Significantly impacted by the knock-out
Homeostasis/metabolism
18 No significant impact
5 Not tested
Data collections
Gene metrics:5Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| increased circulating lipase level | 1 supporting dataset | Pcsk9tm2b(EUCOMM)Hmgu | homozygote | Early adult | 2.14x10-7 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Pcsk9tm2b(EUCOMM)Hmgu | homozygote | Early adult | 5.79x10-25 | ||
| increased circulating alkaline phosphatase level | 1 supporting dataset | Pcsk9tm2b(EUCOMM)Hmgu | homozygote | Early adult | 5.11x10-15 | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Pcsk9tm2b(EUCOMM)Hmgu | homozygote | Early adult | 3.67x10-21 | ||
| increased circulating amylase level | 1 supporting dataset | Pcsk9tm2b(EUCOMM)Hmgu | homozygote | Early adult | 3.59x10-5 |
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External links
No external links available for Pcsk9.
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| Pcsk9em1(IMPC)Ccpcz | Exon Deletion | | mouse |
| Pcsk9tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
| Pcsk9tm2b(EUCOMM)Hmgu | Reporter-tagged deletion allele (with selection cassette) | | mouse |
| Pcsk9tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |
| Pcsk9tm39136(L1L2_st0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |