Mbd5 | methyl-CpG binding domain protein 5

GeneMGI:2138934Synonyms: OTTMUSG00000012483, 9430004D19Rik, +1 more

Physiological systems

19 / 24 physiological systems tested

9 Significantly impacted by the knock-out

Immune system Growth/size/body region Limbs/digits/tail Vision/eye Hematopoietic system Behavior/neurological Skeleton Craniofacial Mortality/aging

10 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

3Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased total retina thickness	2 supporting datasets	Mbd5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	8.68x10^-8
decreased locomotor activity	2 supporting datasets	Mbd5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2x10^-5
decreased leukocyte cell number	1 supporting dataset	Mbd5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	4.96x10^-5
decreased exploration in new environment	1 supporting dataset	Mbd5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	6x10^-7
abnormal lip morphology	1 supporting dataset	Mbd5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.08x10^-5
preweaning lethality, complete penetrance	1 supporting dataset	Mbd5^{tm1b(EUCOMM)Wtsi}	homozygote	Early adult	N/A ^*
short tibia	1 supporting dataset	Mbd5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	1.55x10^-5
decreased lymphocyte cell number	1 supporting dataset	Mbd5^{tm1b(EUCOMM)Wtsi}	heterozygote	Early adult	2.8x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Mbd5.

Associated images

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Histopathology

There is no histopathology data found for Mbd5.

IMPC related publications

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External links

No external links available for Mbd5.

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*Mbd5^{tm1a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Mbd5^{tm1b(EUCOMM)Wtsi}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Mbd5^{tm3a(EUCOMM)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Mbd5^{tm3e(EUCOMM)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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