Park7 | Parkinson disease (autosomal recessive, early onset) 7

GeneMGI:2135637Synonyms: DJ-1

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Skeleton Cardiovascular system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:5Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal head morphology1 supporting datasetPark7em1(IMPC)HhomozygoteEarly adult7.79x10-7 
increased circulating HDL cholesterol level1 supporting datasetPark7em1(IMPC)HhomozygoteLate adult1.13x10-5 
prolonged QRS complex duration1 supporting datasetPark7em1(IMPC)HhomozygoteEarly adult8.92x10-5 
increased circulating serum albumin level1 supporting datasetPark7em1(IMPC)HhomozygoteLate adult2.75x10-5 
decreased bone mineral density1 supporting datasetPark7em1(IMPC)HhomozygoteLate adult4.09x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Park7em1(IMPC)HInter-exon deletionmouse
Park7em2(IMPC)HInter-exon deletionmouse
Park7tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
es cell

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