Tyk2 | tyrosine kinase 2

GeneMGI:1929470Synonyms: JTK1

Physiological systems

23 / 24 physiological systems tested

7 Significantly impacted by the knock-out

Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Growth/size/body region Hematopoietic system Cardiovascular system

16 No significant impact

1 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

4Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



enlarged thymus	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
decreased plasmacytoid dendritic cell number	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	3.13x10^-5
abnormal pancreas morphology	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
increased circulating lactate dehydrogenase level	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	6.2x10^-5
decreased heart left ventricle size	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	2.48x10^-5
abnormal ovary morphology	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
decreased circulating HDL cholesterol level	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	4.49x10^-5
enlarged spleen	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*
abnormal seminal vesicle morphology	1 supporting dataset	Tyk2^{tm2b(EUCOMM)Hmgu}	homozygote	Late adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Tyk2.

Associated images

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Histopathology

There is no histopathology data found for Tyk2.

IMPC related publications

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External links

No external links available for Tyk2.

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*Tyk2^{em1(IMPC)Ccpcz}*	Inter-exon deletion	‌	mouse
*Tyk2^{tm1(NCOM)Mfgc}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector es cell
*Tyk2^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Tyk2^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Tyk2^{tm2a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Tyk2^{tm2b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Tyk2^{tm2e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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