Orai1 | ORAI calcium release-activated calcium modulator 1

GeneMGI:1925542Synonyms: Tmem142a, D730049H07Rik

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Embryo Growth/size/body region Behavior/neurological Mortality/aging Cardiovascular system

16 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:4Significant phenotypes

5Associated diseases

Expression examined in:51Adult tissues

62Embryo tissues

Phenotypes

Zygosity:

Phy. System:

Life Stage:



preweaning lethality, complete penetrance	3 supporting datasets	Orai1^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*
abnormal sinus arrhythmia	1 supporting dataset	Orai1^{tm1b(EUCOMM)Hmgu}	heterozygote	Early adult	6x10^-5
unresponsive to tactile stimuli	1 supporting dataset	Orai1^{tm1b(EUCOMM)Hmgu}	heterozygote	E18.5	N/A ^*
unresponsive to tactile stimuli	1 supporting dataset	Orai1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*
abnormal embryo size	1 supporting dataset	Orai1^{tm1b(EUCOMM)Hmgu}	homozygote	E18.5	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Orai1.

Associated images

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Histopathology

There is no histopathology data found for Orai1.

IMPC related publications

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External links

No external links available for Orai1.

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*Orai1^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Orai1^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Orai1^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell

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