Map4k5 | mitogen-activated protein kinase kinase kinase kinase 5

GeneMGI:1925503Synonyms: GCKR, MAPKKKK5, +2 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

Growth/size/body region Limbs/digits/tail Skeleton Renal/urinary system

15 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:3Significant phenotypes

0Associated diseases

Expression examined in:51Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



short tibia	1 supporting dataset	Map4k5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.82x10^-5
decreased body length	1 supporting dataset	Map4k5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	5.64x10^-5
abnormal kidney morphology	1 supporting dataset	Map4k5^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	N/A ^*

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Map4k5.

Associated images

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Histopathology

There is no histopathology data found for Map4k5.

IMPC related publications

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External links

No external links available for Map4k5.

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*Map4k5^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector ES Cell mouse
*Map4k5^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Map4k5^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	ES Cell

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