Fam53b | family with sequence similarity 53, member B

GeneMGI:1925188Synonyms: A930008G19Rik

Physiological systems

18 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Nervous system Hearing/vestibular/ear Hematopoietic system Cardiovascular system

13 No significant impact

6 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:9Significant phenotypes

0Associated diseases

Expression examined in:70Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular hemoglobin	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.4x10^-20
increased circulating sodium level	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.91x10^-6
decreased erythrocyte cell number	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.29x10^-9
increased circulating fructosamine level	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.84x10^-9
increased mean corpuscular volume	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	7.12x10^-51
decreased red blood cell distribution width	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	2.69x10^-7
decreased prepulse inhibition	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	4.83x10^-7
abnormal auditory brainstem response	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.04x10^-5
increased cardiac stroke volume	1 supporting dataset	Fam53b^{tm1b(EUCOMM)Hmgu}	homozygote	Early adult	1.26x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Fam53b.

Associated images

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Histopathology

There is no histopathology data found for Fam53b.

IMPC related publications

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External links

No external links available for Fam53b.

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*Fam53b^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	es cell
*Fam53b^{tm1a(EUCOMM)Hmgu}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell mouse
*Fam53b^{tm1b(EUCOMM)Hmgu}*	Reporter-tagged deletion allele (with selection cassette)	‌	mouse
*Fam53b^{tm1e(EUCOMM)Hmgu}*	Targeted, non-conditional allele	‌	es cell
*Fam53b^{tm41826(L1L2_gt0)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

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