Sla2 | Src-like-adaptor 2

GeneMGI:1925049Synonyms: SLAP-2, A930009E21Rik, +1 more

Physiological systems

21 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Immune system Integument Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Craniofacial

13 No significant impact

3 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:8Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Phy. System:



decreased NK cell number	1 supporting dataset	Sla2^{em1(IMPC)Ccpcz}	homozygote	Early adult	4.15x10^-5
decreased body weight	1 supporting dataset	Sla2^{em1(IMPC)Ccpcz}	homozygote	Early adult	7.51x10^-9
abnormal skin morphology	1 supporting dataset	Sla2^{em1(IMPC)Ccpcz}	homozygote	Early adult	N/A ^*
increased circulating HDL cholesterol level	1 supporting dataset	Sla2^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.56x10^-6
increased circulating cholesterol level	1 supporting dataset	Sla2^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.66x10^-6
increased circulating total protein level	1 supporting dataset	Sla2^{em1(IMPC)Ccpcz}	homozygote	Early adult	1.05x10^-6
abnormal cranium morphology	1 supporting dataset	Sla2^{em1(IMPC)Ccpcz}	homozygote	Early adult	2.9x10^-7
enhanced cued conditioning behavior	1 supporting dataset	Sla2^{em1(IMPC)Ccpcz}	homozygote	Early adult	3.99x10^-6

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Sla2.

Associated images

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Histopathology

There is no histopathology data found for Sla2.

IMPC related publications

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External links

No external links available for Sla2.

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*Sla2^{em1(IMPC)Ccpcz}*	Exon Deletion	‌	mouse
*Sla2^{tm1a(KOMP)Wtsi}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector es cell
*Sla2^{tm1e(KOMP)Wtsi}*	Targeted, non-conditional allele	‌	es cell

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